Description of a novel polymorphic gene encoding for arylamine N-acetyltransferase in the rhesus macaque (Macaca mulatta), a model animal for endometriosis.

Journal article

OBJECTIVES: Case-control studies have previously associated polymorphisms in the gene encoding the xenobiotic metabolizing enzyme arylamine N-acetyltransferase 2 (NAT2) with endometriosis, a common multifactorial disease in women. These studies, however, have been problematic on methodological grounds and their results are inconclusive. To better understand the possible relationship between the NAT2 gene and endometriosis, we characterized its homologue in the rhesus macaque, an animal model...

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Authors: Fakis, G; Boukouvala, S; Kawamura, A; Kennedy, S

• Publication status: Published
• Journal: Pharmacogenetics and genomics
• Volume: 17
• Issue: 3
• Pages: 181-188
• Publication date: 2007-03-01
• DOI: 10.1097/fpc.0b013e328011e3ad
• EISSN: 1744-6880
• ISSN: 1744-6872
• Language: English
• Keywords: Base Sequence; Disease Models, Animal; Cricetinae; DNA Mutational Analysis; Arylamine N-Acetyltransferase; Humans; Recombinant Proteins; Endometriosis; Molecular Sequence Data; Animals; Polymorphism, Genetic; Macaca mulatta; CHO Cells; Sequence Homology; Isoenzymes; Amino Acid Sequence; Female; Cricetulus