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Low density lipoprotein receptor-related protein 1 (LRP1)-mediated endocytic clearance of a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4): functional differences of non-catalytic domains of ADAMTS-4 and ADAMTS-5 in LRP1 binding.

Abstract:

Degradation of the cartilage proteoglycan aggrecan is an early event in the development of osteoarthritis, and a disintegrin and metalloproteinase with thrombospondin motifs-4 (ADAMTS-4) and ADAMTS-5 are considered to be the major aggrecan-degrading enzymes. We have recently found that ADAMTS-5 is rapidly endocytosed via low density lipoprotein receptor-related protein 1 (LRP1) and degraded by chondrocytes. Here we report that this regulatory mechanism also applies to ADAMTS-4, although its r...

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Publication status:
Published

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Publisher copy:
10.1074/jbc.m113.545376

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Publisher:
American Society for Biochemistry and Molecular Biology Inc.
Journal:
Journal of biological chemistry
Volume:
289
Issue:
10
Pages:
6462-6474
Publication date:
2014-03-01
DOI:
EISSN:
1083-351X
ISSN:
0021-9258
Source identifiers:
447740
Language:
English
Keywords:
Pubs id:
pubs:447740
UUID:
uuid:cc6217b0-ef28-43c3-985a-e212b2824c7f
Local pid:
pubs:447740
Deposit date:
2014-02-23

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