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Gene-environment interaction research and transgenic mouse models of Alzheimer's disease.

Abstract:

The etiology of the sporadic form of Alzheimer's disease (AD) remains largely unknown. Recent evidence has suggested that gene-environment interactions (GxE) may play a crucial role in its development and progression. Whereas various susceptibility loci have been identified, like the apolipoprotein E4 allele, these cannot fully explain the increasing prevalence of AD observed with aging. In addition to such genetic risk factors, various environmental factors have been proposed to alter the ri...

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Publisher copy:
10.4061/2010/859101

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Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
Journal:
International journal of Alzheimer's disease
Volume:
2010
Pages:
113-120
Publication date:
2010-01-01
DOI:
EISSN:
2090-0252
ISSN:
2090-8024
Language:
English
Pubs id:
pubs:456150
UUID:
uuid:cc5efb1f-407b-49c2-81d6-2b67307f368e
Local pid:
pubs:456150
Source identifiers:
456150
Deposit date:
2014-05-13

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