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Association of blood lipids with Alzheimer's disease: A comprehensive lipidomics analysis

Abstract:

INTRODUCTION: The aim of this study was to (1) replicate previous associations between six blood lipids and Alzheimer's disease (AD) (Proitsi et al 2015) and (2) identify novel associations between lipids, clinical AD diagnosis, disease progression and brain atrophy (left/right hippocampus/entorhinal cortex).

METHODS: We performed untargeted lipidomic analysis on 148 AD and 152 elderly control plasma samples and used univariate and multivariate analysis methods.

RESULTS: We r...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.jalz.2016.08.003

Authors


More from this funder
Name:
European Union
Grant:
HEALTH-F4-2009-242257
115372
115372
Funding agency for:
Dobson, R
Legido-Quigley, C
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Name:
National Institute for Health Research
Grant:
MR/K006584/1/
More from this funder
Name:
Alzheimer's Society
Funding agency for:
Proitsi, P
Publisher:
Elsevier
Journal:
Alzheimer's & Dementia More from this journal
Volume:
13
Issue:
2
Pages:
140-151
Publication date:
2016-09-28
DOI:
EISSN:
1552-5279
ISSN:
1552-5260
Language:
English
Keywords:
Pubs id:
pubs:652924
UUID:
uuid:cc49ed90-6730-430e-9dae-b1d59cad9490
Local pid:
pubs:652924
Source identifiers:
652924
Deposit date:
2017-07-24

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