Repair of abasic sites in DNA.

Journal article

Repair of both normal and reduced AP sites is activated by AP endonuclease, which recognizes and cleaves a phosphodiester bond 5' to the AP site. For a short period of time an incised AP site is occupied by poly(ADP-ribose) polymerase and then DNA polymerase beta adds one nucleotide into the repair gap and simultaneously removes the 5'-sugar phosphate. Finally, the DNA ligase III/XRCC1 complex accomplishes repair by sealing disrupted DNA ends. However, long-patch BER pathway, which is involve...

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Authors: Dianov, G; Sleeth, K; Dianova, I; Allinson, S

• Publication status: Published
• Journal: Mutation research
• Volume: 531
• Issue: 1-2
• Pages: 157-163
• Publication date: 2003-10-01
• DOI: 10.1016/j.mrfmmm.2003.09.003
• EISSN: 1873-135X
• ISSN: 0027-5107
• Language: English
• Keywords: DNA Repair; Base Sequence; Molecular Sequence Data