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Repair of abasic sites in DNA.

Abstract:

Repair of both normal and reduced AP sites is activated by AP endonuclease, which recognizes and cleaves a phosphodiester bond 5' to the AP site. For a short period of time an incised AP site is occupied by poly(ADP-ribose) polymerase and then DNA polymerase beta adds one nucleotide into the repair gap and simultaneously removes the 5'-sugar phosphate. Finally, the DNA ligase III/XRCC1 complex accomplishes repair by sealing disrupted DNA ends. However, long-patch BER pathway, which is involve...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Oncology
Role:
Author
Journal:
Mutation research More from this journal
Volume:
531
Issue:
1-2
Pages:
157-163
Publication date:
2003-10-01
DOI:
EISSN:
1873-135X
ISSN:
0027-5107
Language:
English
Keywords:
Pubs id:
pubs:131064
UUID:
uuid:cc2e8191-7f9a-4964-94be-aae3850f2297
Local pid:
pubs:131064
Source identifiers:
131064
Deposit date:
2013-11-16

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