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Towards optimal regimens of parenteral quinine for young African children with cerebral malaria: unbound quinine concentrations following a simple loading dose regimen.

Abstract:

Nine children with severe falciparum malaria were treated with an intravenous quinine regimen which did not require burettes or infusion pumps, to determine its practicability and to ensure that therapeutic drug concentrations were achieved and maintained throughout the dose interval. The regimen comprised quinine dihydrochloride (15 mg/kg; 12.5 mg/kg of the free base), which was added to a bag of intravenous fluid (after wastage of all but 100 mL), and given via standard giving sets over 2 h...

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Publication status:
Published

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Journal:
Transactions of the Royal Society of Tropical Medicine and Hygiene More from this journal
Volume:
88
Issue:
5
Pages:
577-580
Publication date:
1994-01-01
DOI:
EISSN:
1878-3503
ISSN:
0035-9203
Language:
English
Keywords:
Pubs id:
pubs:44656
UUID:
uuid:cc283602-c58e-45ae-afd4-7d556029296a
Local pid:
pubs:44656
Source identifiers:
44656
Deposit date:
2012-12-19

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