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Journal article

Rapid generation of markerless recombinant MVA vaccines by en passant recombineering of a self-excising bacterial artificial chromosome.

Abstract:

The non-replicating poxviral vector modified vaccinia virus Ankara (MVA) is currently a leading candidate for development of novel recombinant vaccines against globally important diseases. The 1980s technology for making recombinant MVA (and other poxviruses) is powerful and robust, but relies on rare recombination events in poxviral-infected cells. In the 21st century, it has become possible to apply bacterial artificial chromosome (BAC) technology to poxviruses, as first demonstrated by B. ...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute
Role:
Author
Journal:
Journal of virological methods
Volume:
168
Issue:
1-2
Pages:
233-236
Publication date:
2010-09-05
DOI:
EISSN:
1879-0984
ISSN:
0166-0934
URN:
uuid:cc236ba1-6754-4535-a76c-70321aa16403
Source identifiers:
54656
Local pid:
pubs:54656

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