Rate-dependent response of axonal microtubules and tau proteins under shear forces

Journal article

Abstract. The brain tissue is a very complex biological material exhibiting viscoelastic-type properties at the macroscopic level, arising from a hierarchical multiscale structure. Thus, to describe such interesting features at the molecular level, we introduce a model mimicking the coupling of microtubules and tau proteins inside the neuronal axon and we study the rate-dependent response under different conditions of applied load, rate, and temperature.

Authors: Bellino, L

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Materials Research Forum
• Journal: Materials Research Proceedings (MRP)
• Volume: 26
• Pages: 65-70
• Publication date: 2023-02-26
• DOI: 10.21741/9781644902431-11
• ISSN: 2474-3941
• Language: English
• Keywords: Cell biology; Viscoelasticity; Materials science; Biology; Axon; Thermodynamics; Physics; Microtubule; Neurophysiology; Composite material; Biophysics; Neuroscience; Biological system; Coupling (piping)