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Correlation of memory T cell responses against TRAP with protection from clinical malaria, and CD4^+ CD25 ^high T cells with susceptibility in Kenyans

Abstract:

Background: Immunity to malaria develops naturally in endemic regions, but the protective immune mechanisms are poorly understood. Many vaccination strategies aim to induce T cells against divers pre-erythrocytic antigens, but correlates of protection in the field have been limited. The objective of this study was to investigate cell-mediated immune correlates of protection in natural malaria. Memory T cells reactive against thrombospondin-related adhesive protein (TRAP) and circumsporozoite ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0002027

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Institution:
"University of Oxford", "Kenya Medical Research Institute (KEMRI) - Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya", "Northumbria University, Newcastle-upon-Tyne, UK"
Department:
School of Applied Sciences
Role:
Author
More by this author
Institution:
"University of Oxford", "Kenya Medical Research Institute (KEMRI) - Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More by this author
Institution:
"Kenya Medical Research Institute (KEMRI) - Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Role:
Author
More by this author
Institution:
"Monash University, Clayton, Victoria, Australia"
Department:
Department of Immunology
Role:
Author
More by this author
Institution:
"University of Oxford", "Kenya Medical Research Institute (KEMRI) - Wellcome Trust Collaborative Research Programme, Centre for Geographic Medicine Research (Coast), Kilifi, Kenya"
Department:
Medical Sciences Division - Clinical Vaccinology and Tropical Medicine,Centre for (CCVTM)
Role:
Author
More from this funder
Name:
Wellcome Trust
Funding agency for:
Hill, A
Flanagan, K
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
3
Issue:
4
Article number:
e2027
Publication date:
2008-04-01
DOI:
EISSN:
1932-6203
Language:
English
Keywords:
Subjects:
UUID:
uuid:cc0c4d33-6ebf-4c1c-9a6d-ed6e0d4515b3
Local pid:
ora:2500
Deposit date:
2009-01-09

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