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An altered position of the alpha 2 helix of MHC class I is revealed by the crystal structure of HLA-B*3501.

Abstract:

The crystal structure of the human major histocompatibility complex class I B allele HLA B*3501 complexed with the 8-mer peptide epitope HIV1 Nef 75-82 (VPLRPMTY) has been determined at 2.0 angstrom resolution. Comparison with the crystal structure of the closely related allele HLA B*5301 reveals the structural basis for the tyrosine specificity of the B*3501 F pocket. The structure also reveals a novel conformation of the 8-mer peptide within the binding groove. The positions of the peptide ...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Biology
Role:
Author
Journal:
Immunity More from this journal
Volume:
4
Issue:
3
Pages:
203-213
Publication date:
1996-03-01
DOI:
EISSN:
1097-4180
ISSN:
1074-7613
Language:
English
Keywords:
Pubs id:
pubs:14436
UUID:
uuid:cc03de49-e408-4914-be81-94447af0ff67
Local pid:
pubs:14436
Source identifiers:
14436
Deposit date:
2012-12-19

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