Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood.

Journal article

Neuregulin-1 (NRG1) plays a crucial role in axoglial signaling during the development of the peripheral nervous system, but its importance in adulthood after peripheral nerve injury remains unclear. We used single-neuron labeling with inducible Cre-mediated knock-out animals, which enabled visualization of a subset of adult myelinated sensory and motoneurons neurons in which Nrg1 was inducibly mutated by tamoxifen treatment. In uninjured mice, NRG1-deficient axons and the associated myelin sh...

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Authors: Fricker, F; Lago, N; Balarajah, S; Tsantoulas, C; Tanna, S

• Journal: Journal of neuroscience : the official journal of the Society for Neuroscience
• Volume: 31
• Issue: 9
• Pages: 3225-3233
• Publication date: 2011-03-01
• DOI: 10.1523/jneurosci.2568-10.2011
• EISSN: 1529-2401
• ISSN: 0270-6474
• Language: English
• Keywords: Myelin Sheath; Mice; Mice, Transgenic; Neuromuscular Junction; Sciatic Neuropathy; Mice, Knockout; Mice, Inbred C57BL; Neuregulin-1; Nerve Regeneration; Axons; Nerve Fibers, Myelinated; Animals; Aging