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Axonally derived neuregulin-1 is required for remyelination and regeneration after nerve injury in adulthood.

Abstract:

Neuregulin-1 (NRG1) plays a crucial role in axoglial signaling during the development of the peripheral nervous system, but its importance in adulthood after peripheral nerve injury remains unclear. We used single-neuron labeling with inducible Cre-mediated knock-out animals, which enabled visualization of a subset of adult myelinated sensory and motoneurons neurons in which Nrg1 was inducibly mutated by tamoxifen treatment. In uninjured mice, NRG1-deficient axons and the associated myelin sh...

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience More from this journal
Volume:
31
Issue:
9
Pages:
3225-3233
Publication date:
2011-03-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Language:
English
Keywords:
Pubs id:
pubs:365742
UUID:
uuid:cbfb3874-51a4-42d1-88a7-a4a912f25112
Local pid:
pubs:365742
Source identifiers:
365742
Deposit date:
2013-11-16

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