Journal article
Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.
- Abstract:
-
Gene therapy offers a radical different approach to the treatment of arthritis. Here we have demonstrated that two marker genes (lacZ and neo) and cDNA coding for a potentially therapeutic protein (human interleukin 1-receptor-antagonist protein; IRAP or IL-1ra) can be delivered, by ex vivo techniques, to the synovial lining of joints; intraarticular expression of IRAP inhibited intraarticular responses to interleukin 1. To achieve this, lapine synoviocytes were first transduced in culture by...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.90.22.10764
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 90
- Issue:
- 22
- Pages:
- 10764-10768
- Publication date:
- 1993-11-01
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
466405
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:466405
- UUID:
-
uuid:cbc1b0f8-66c3-4148-8236-2498b4b2786b
- Local pid:
- pubs:466405
- Deposit date:
- 2014-06-18
Terms of use
- Copyright date:
- 1993
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