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Journal article

Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.

Abstract:

Gene therapy offers a radical different approach to the treatment of arthritis. Here we have demonstrated that two marker genes (lacZ and neo) and cDNA coding for a potentially therapeutic protein (human interleukin 1-receptor-antagonist protein; IRAP or IL-1ra) can be delivered, by ex vivo techniques, to the synovial lining of joints; intraarticular expression of IRAP inhibited intraarticular responses to interleukin 1. To achieve this, lapine synoviocytes were first transduced in culture by...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.90.22.10764

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
90
Issue:
22
Pages:
10764-10768
Publication date:
1993-11-01
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
466405
Language:
English
Keywords:
Pubs id:
pubs:466405
UUID:
uuid:cbc1b0f8-66c3-4148-8236-2498b4b2786b
Local pid:
pubs:466405
Deposit date:
2014-06-18

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