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Structural basis for hijacking siderophore receptors by antimicrobial lasso peptides

Abstract:
The lasso peptide microcin J25 is known to hijack the siderophore receptor FhuA for initiating internalization. Here, we provide what is to our knowledge the first structural evidence on the recognition mechanism, and our biochemical data show that another closely related lasso peptide cannot interact with FhuA. Our work provides an explanation on the narrow activity spectrum of lasso peptides and opens the path to the development of new antibacterials.© 2014 Nature America, Inc. All rights reserved.

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Publisher copy:
10.1038/nchembio.1499

Authors


Mathavan, I More by this author
Mehmood, S More by this author
Choudhury, HG More by this author
Goulard, C More by this author
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Publisher:
Nature Publishing Group
Journal:
Nature Chemical Biology
Volume:
10
Issue:
5
Pages:
340-342
Publication date:
2014
DOI:
EISSN:
1552-4469
ISSN:
1552-4450
URN:
uuid:cbb6a1bc-90de-4d36-96bb-db3b2a3f5e56
Source identifiers:
466870
Local pid:
pubs:466870
Language:
English

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