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On the structure of prilocaine in aqueous and amphiphilic solutions

Abstract:

The solvation of prilocaine has been investigated in pure water and in an amphiphilic methanol/water solution using a combination of neutron diffraction with isotopic substitution augmented by Empirical Potential Structure Refinement (EPSR) simulations. This combination of techniques allows for details of the solvation structure on the atomic scale to be unravelled. The hydration of prilocaine is significantly altered relative to when this molecule is in pure water (as a hydrochloride salt) o...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1039/c7cp01723e

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Name:
Government of Catalonia
Grant:
2014SGR-00581
2009SGR-1003
More from this funder
Name:
Ministerio de Economía, Industria y Competitividad
Grant:
FIS2014a-54734-P
FIS2012-39443-C02-01
More from this funder
Name:
Engineering and Physical Sciences Research Council
Grant:
EP/J002615/1
Publisher:
Royal Society of Chemistry
Journal:
Physical Chemistry Chemical Physics More from this journal
Volume:
19
Issue:
20
Pages:
12665-12673
Publication date:
2017-05-05
Acceptance date:
2017-04-25
DOI:
EISSN:
1463-9084
ISSN:
1463-9076
Language:
English
Pubs id:
pubs:693926
UUID:
uuid:cb93748d-ac74-423b-83f7-169deef8b5e2
Local pid:
pubs:693926
Source identifiers:
693926
Deposit date:
2017-05-09

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