Journal article
Small-molecule inhibition of BRDT for male contraception.
- Abstract:
-
A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling during spermatogenesis. Biochemical and crystallographic studies confirm that occupancy of the BRDT...
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- Publication status:
- Published
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- Publisher copy:
- 10.1016/j.cell.2012.06.045
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Authors
Bibliographic Details
- Journal:
- Cell
- Volume:
- 150
- Issue:
- 4
- Pages:
- 673-684
- Publication date:
- 2012-08-01
- DOI:
- EISSN:
-
1097-4172
- ISSN:
-
0092-8674
- Source identifiers:
-
349867
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:349867
- UUID:
-
uuid:cb8d8584-2956-4e14-899a-838a17c77436
- Local pid:
- pubs:349867
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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