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Journal article

Small-molecule inhibition of BRDT for male contraception.

Abstract:

A pharmacologic approach to male contraception remains a longstanding challenge in medicine. Toward this objective, we explored the spermatogenic effects of a selective small-molecule inhibitor (JQ1) of the bromodomain and extraterminal (BET) subfamily of epigenetic reader proteins. Here, we report potent inhibition of the testis-specific member BRDT, which is essential for chromatin remodeling during spermatogenesis. Biochemical and crystallographic studies confirm that occupancy of the BRDT...

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Publication status:
Published

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Publisher copy:
10.1016/j.cell.2012.06.045

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Author
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Journal:
Cell
Volume:
150
Issue:
4
Pages:
673-684
Publication date:
2012-08-01
DOI:
EISSN:
1097-4172
ISSN:
0092-8674
Source identifiers:
349867
Language:
English
Keywords:
Pubs id:
pubs:349867
UUID:
uuid:cb8d8584-2956-4e14-899a-838a17c77436
Local pid:
pubs:349867
Deposit date:
2012-12-19

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