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Evidence of widespread cerebral microglial activation in amyotrophic lateral sclerosis: an [11C](R)-PK11195 positron emission tomography study.

Abstract:

Microglial activation is implicated in the pathogenesis of ALS and can be detected in animal models of the disease that demonstrate increased survival when treated with anti-inflammatory drugs. PK11195 is a ligand for the "peripheral benzodiazepine binding site" expressed by activated microglia. Ten ALS patients and 14 healthy controls underwent [(11)C](R)-PK11195 PET of the brain. Volumes of interest were defined to obtain [(11)C](R)-PK11195 regional binding potential values for motor and "e...

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Publication status:
Published

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Publisher copy:
10.1016/j.nbd.2003.12.012

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Neurobiology of disease More from this journal
Volume:
15
Issue:
3
Pages:
601-609
Publication date:
2004-04-01
DOI:
EISSN:
1095-953X
ISSN:
0969-9961
Language:
English
Keywords:
Pubs id:
pubs:373960
UUID:
uuid:cb884522-a2ea-4604-aa7c-b9f782c3ce64
Local pid:
pubs:373960
Source identifiers:
373960
Deposit date:
2013-11-16

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