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Determination of an adequate perfusion pressure for continuous dual vessel hypothermic machine perfusion of the rat liver.

Abstract:

Hypothermic machine perfusion (HMP) provides better protection against ischemic damage of the kidney compared to cold-storage. The required perfusion pressures needed for optimal HMP of the liver are, however, unknown. Rat livers were preserved in University of Wisconsin organ preservation solution enriched with acridine orange (AO) to stain viable cells and propidium iodide (PI) to detect dead cells. Perfusion pressures of 12.5%, 25% or 50% of physiologic perfusion pressures were compared. I...

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Publication status:
Published

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Authors


't Hart, NA More by this author
der van Plaats, A More by this author
Leuvenink, HG More by this author
van Goor, H More by this author
Wiersema-Buist, J More by this author
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Journal:
Transplant international : official journal of the European Society for Organ Transplantation
Volume:
20
Issue:
4
Pages:
343-352
Publication date:
2007-04-05
DOI:
EISSN:
1432-2277
ISSN:
0934-0874
URN:
uuid:cb76c853-c8ad-4628-b0a6-54fa327e9d00
Source identifiers:
190860
Local pid:
pubs:190860

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