The human T lymphocyte receptor complex for antigen and MHC.

Journal article

Recent studies using cloned antigen specific T lymphocytes and monoclonal antibodies directed at their various surface glycoprotein components have led to identification of the human T cell antigen receptor as a surface complex comprised of a clonotypic 90 KD Ti heterodimer and the in-variant 20 and 25 KD T3 molecules. Approximately 30,000-40,000 Ti and T3 molecules exist on the surface of human T lymphocytes. These glycoproteins are acquired and expressed during late thymic ontogeny, thus pr...

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Authors: Royer, H; Campen, T; Ramarli, D; Chang, H; Acuto, O

• Journal: Behring Institute Mitteilungen
• Issue: 77
• Pages: 1-21
• Publication date: 1985-08-01
• ISSN: 0301-0457
• Language: English
• Keywords: Interleukin-2; Humans; Antigens, Surface; Amino Acid Sequence; Antibodies, Monoclonal; T-Lymphocytes, Cytotoxic; Genes; Cell Membrane; T-Lymphocytes, Helper-Inducer; Protein Conformation; Receptors, Antigen, T-Cell; Lymphocyte Activation; Cell Differentiation; Clone Cells; Antigens, Differentiation, T-Lymphocyte; T-Lymphocytes; Membrane Proteins; Molecular Weight; Macromolecular Substances; Major Histocompatibility Complex