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Structure of the CRISPR interference complex CSM reveals key similarities with cascade.

Abstract:

The Clustered Regularly Interspaced Palindromic Repeats (CRISPR) system is an adaptive immune system in prokaryotes. Interference complexes encoded by CRISPR-associated (cas) genes utilize small RNAs for homology-directed detection and subsequent degradation of invading genetic elements, and they have been classified into three main types (I-III). Type III complexes share the Cas10 subunit but are subclassifed as type IIIA (CSM) and type IIIB (CMR), depending on their specificity for DNA or R...

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Publication status:
Published

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Journal:
Molecular cell
Volume:
52
Issue:
1
Pages:
124-134
Publication date:
2013-10-01
DOI:
EISSN:
1097-4164
ISSN:
1097-2765
Source identifiers:
434224

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