- Abstract:
-
Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a r...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1038/ng1450
-
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- Journal:
- Nature genetics
- Volume:
- 36
- Issue:
- 11
- Pages:
- 1197-1202
- Publication date:
- 2004-11-05
- DOI:
- EISSN:
-
1546-1718
- ISSN:
-
1061-4036
- URN:
-
uuid:cb1c62b6-b89e-4043-923b-d3eb15b8f26b
- Source identifiers:
-
29519
- Local pid:
- pubs:29519
- Copyright date:
- 2004
Journal article
Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.
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