Journal article icon

Journal article

Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice.

Abstract:

Here we present a strategy to determine the genetic basis of variance in complex phenotypes that arise from natural, as opposed to induced, genetic variation in mice. We show that a commercially available strain of outbred mice, MF1, can be treated as an ultrafine mosaic of standard inbred strains and accordingly used to dissect a known quantitative trait locus influencing anxiety. We also show that this locus can be subdivided into three regions, one of which contains Rgs2, which encodes a r...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1038/ng1450

Authors


Willis-Owen, SA More by this author
Fullerton, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Experimental Psychology
Expand authors...
Journal:
Nature genetics
Volume:
36
Issue:
11
Pages:
1197-1202
Publication date:
2004-11-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:cb1c62b6-b89e-4043-923b-d3eb15b8f26b
Source identifiers:
29519
Local pid:
pubs:29519

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP