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Understanding stem cell immunogenicity in therapeutic applications

Abstract:

Stem cells and their differentiated progeny offer great hope for treating disease by providing an unlimited source of cells for repairing or replacing damaged tissue. Initial studies suggested that, unlike 'normal' transplants, specific characteristics of stem cells enabled them to avoid immune attack. However, recent findings have revealed that the immunogenicity of stem cells may have been underestimated. Here, we review the current understanding of the mechanisms of immune recognition asso...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.it.2015.11.005

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Publisher:
Cell Press
Journal:
Trends in Immunology More from this journal
Volume:
37
Issue:
1
Pages:
5-16
Publication date:
2015-12-11
DOI:
EISSN:
1471-4981
ISSN:
1471-4906
Language:
English
Pubs id:
pubs:586305
UUID:
uuid:cb0f490f-fc6c-41d1-9c9d-a2be10bb9631
Local pid:
pubs:586305
Source identifiers:
586305
Deposit date:
2016-02-01

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