Elucidating the interactions between the adhesive and transcriptional functions of beta-catenin in normal and cancerous cells.

Journal article

Wnt signalling is involved in a wide range of physiological and pathological processes. The presence of an extracellular Wnt stimulus induces cytoplasmic stabilisation and nuclear translocation of beta-catenin, a protein that also plays an essential role in cadherin-mediated adhesion. Two main hypotheses have been proposed concerning the balance between beta-catenin's adhesive and transcriptional functions: either beta-catenin's fate is determined by competition between its binding partners, ...

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Authors: van Leeuwen, I; Byrne, H; Jensen, O; King, JR

• Publication status: Published
• Journal: Journal of theoretical biology
• Volume: 247
• Issue: 1
• Pages: 77-102
• Publication date: 2007-07-01
• DOI: 10.1016/j.jtbi.2007.01.019
• EISSN: 1095-8541
• ISSN: 0022-5193
• Language: English
• Keywords: Colorectal Neoplasms; Wnt Proteins; Neoplasm Proteins; Signal Transduction; Cell Adhesion; Genes, APC; beta Catenin; Mutation; Transcription, Genetic; Models, Biological; Cadherins; Humans; Cell Transformation, Neoplastic