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Development of a novel enzyme/prodrug combination for gene therapy of cancer: horseradish peroxidase/indole-3-acetic acid.

Abstract:

This paper demonstrates the potential for utilizing the plant enzyme, horseradish peroxidase (HRP), in a gene-directed enzyme prodrug therapy context. Human T24 bladder carcinoma cells transfected with a mammalian expression vector containing the HRP cDNA were selectively sensitized to the nontoxic plant hormone, indole-3-acetic acid (IAA). The HRP/IAA-induced cell kill was effective in normoxic and anoxic conditions. The activated drug is a long-lived species able to cross cell membranes, an...

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Publisher copy:
10.1038/sj.cgt.7700258

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Oncology
Wardman, P More by this author
Journal:
Cancer gene therapy
Volume:
7
Issue:
11
Pages:
1414-1420
Publication date:
2000-11-05
DOI:
EISSN:
1476-5500
ISSN:
0929-1903
URN:
uuid:cb0a0fb4-78f1-466c-b05c-5d9167cfd0c6
Source identifiers:
272403
Local pid:
pubs:272403

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