Journal article : Review

Neuroinflammation associated with ultrasound-mediated permeabilization of the blood–brain barrier

Abstract:: The blood–brain barrier (BBB) continues to represent one of the most significant challenges for successful drug-based treatments of neurological disease. Mechanical modulation of the BBB using focused ultrasound (FUS) and microbubbles (MBs) has shown considerable promise in enhancing the delivery of therapeutics to the brain, but questions remain regarding possible long-term effects of such forced disruption. This review examines the evidence for inflammation associated with ultrasound-induced BBB disruption and potential strategies for managing such inflammatory effects to improve both the efficacy and safety of therapeutic ultrasound in neurological applications.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Jung, O., Thomas, A., Burks, S. R., Dustin, M. L., Frank, J. A., Ferrer, M., & Stride, E. (2022). Neuroinflammation associated with ultrasound-mediated permeabilization of the blood–brain barrier. Trends in Neurosciences, 45(6), 459–470.

MLA Style

Jung, O., et al. “Neuroinflammation Associated with Ultrasound-Mediated Permeabilization of the Blood–Brain Barrier.” Trends in Neurosciences, vol. 45, no. 6, Cell Press, 2022, pp. 459–70.

Chicago Style

Jung, O, A Thomas, SR Burks, ML Dustin, JA Frank, M Ferrer, and E Stride. 2022. “Neuroinflammation Associated with Ultrasound-Mediated Permeabilization of the Blood–Brain Barrier.” Trends in Neurosciences 45 (6): 459–70.
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Files:: Jung_et_al_2022_Neuroinflammation_associated_with.pdf

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Publisher copy:: 10.1016/j.tins.2022.03.003

Authors

+ Jung, O More by this author

Role:: Author
ORCID:: 0000-0001-6021-1270

+ Thomas, A More by this author

Role:: Author

+ Burks, SR More by this author

Role:: Author

+ Dustin, ML More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Sub department:: Kennedy Institute for Rheumatology
Role:: Author
ORCID:: 0000-0003-4983-6389

+ Frank, JA More by this author

Role:: Author

More authors...

+ Kennedy Trust for Rheumatology Research More from this funder

Grant:: 20 21 17

Publisher:: Cell Press
Journal:: Trends in Neurosciences More from this journal
Volume:: 45
Issue:: 6
Pages:: 459-470
Publication date:: 2022-04-20
Acceptance date:: 2022-03-11
DOI:: 10.1016/j.tins.2022.03.003
EISSN:: 1878-108X
ISSN:: 0166-2236

Language:: English
Keywords:: FFR
Subtype:: Review
Pubs id:: 1254652
Local pid:: pubs:1254652
Deposit date:: 2022-05-07

Terms of use

Copyright holder:: Jung et al.
Copyright date:: 2022
Rights statement:: © 2022 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

Licence:: CC Attribution (CC BY)

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