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Regulation of angiogenesis by hypoxia: role of the HIF system.

Abstract:

The regulation of angiogenesis by hypoxia is an important component of homeostatic mechanisms that link vascular oxygen supply to metabolic demand. Molecular characterization of angiogenic pathways, identification of hypoxia-inducible factor (HIF) as a key transcriptional regulator of these molecules, and the definition of the HIF hydoxylases as a family of dioxygenases that regulate HIF in accordance with oxygen availability have provided new insights into this process. Here we review these ...

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Publication status:
Published

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Publisher copy:
10.1038/nm0603-677

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
CCMP
Role:
Author
Journal:
Nature medicine More from this journal
Volume:
9
Issue:
6
Pages:
677-684
Publication date:
2003-06-01
DOI:
EISSN:
1546-170X
ISSN:
1078-8956

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