Regulation of angiogenesis by hypoxia: role of the HIF system.

Journal article

The regulation of angiogenesis by hypoxia is an important component of homeostatic mechanisms that link vascular oxygen supply to metabolic demand. Molecular characterization of angiogenic pathways, identification of hypoxia-inducible factor (HIF) as a key transcriptional regulator of these molecules, and the definition of the HIF hydoxylases as a family of dioxygenases that regulate HIF in accordance with oxygen availability have provided new insights into this process. Here we review these ...

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Authors: Pugh, C; Ratcliffe, P

• Publication status: Published
• Journal: Nature medicine
• Volume: 9
• Issue: 6
• Pages: 677-684
• Publication date: 2003-06-01
• DOI: 10.1038/nm0603-677
• EISSN: 1546-170X
• ISSN: 1078-8956
• Language: English
• Keywords: Transcription Factors; Hydroxylation; Anoxia; Hypoxia-Inducible Factor 1; Animals; Protein Subunits; Hypoxia-Inducible Factor 1, alpha Subunit; Neovascularization, Physiologic; Neoplasms; Neovascularization, Pathologic; DNA-Binding Proteins; Humans; Nuclear Proteins; Protein Isoforms; Gene Expression Regulation, Developmental