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HMGB1 is an endogenous immune adjuvant released by necrotic cells.

Abstract:

Immune responses against pathogens require that microbial components promote the activation of antigen-presenting cells (APCs). Autoimmune diseases and graft rejections occur in the absence of pathogens; in these conditions, endogenous molecules, the so-called 'innate adjuvants', activate APCs. Necrotic cells contain and release innate adjuvants; necrotic cells also release high-mobility group B1 protein (HMGB1), an abundant and conserved constituent of vertebrate nuclei. Here, we show that n...

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Publication status:
Published

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Publisher copy:
10.1038/sj.embor.7400205

Authors


Journal:
EMBO reports More from this journal
Volume:
5
Issue:
8
Pages:
825-830
Publication date:
2004-08-01
DOI:
EISSN:
1469-3178
ISSN:
1469-221X
Language:
English
Keywords:
Pubs id:
pubs:374162
UUID:
uuid:cad81f4d-0c22-4c20-8fd8-d30c873671dc
Local pid:
pubs:374162
Source identifiers:
374162
Deposit date:
2013-11-17

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