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Journal article

Limitations to adaptive homeostasis in an hyperoxia-induced model of accelerated ageing.

Abstract:

The Nrf2 signal transduction pathway plays a major role in adaptive responses to oxidative stress and in maintaining adaptive homeostasis, yet Nrf2 signaling undergoes a significant age-dependent decline that is still poorly understood. We used mouse embryonic fibroblasts (MEFs) cultured under hyperoxic conditions of 40% O2, as a model of accelerated ageing. Hyperoxia increased baseline levels of Nrf2 and multiple transcriptional targets (20S Proteasome, Immunoproteasome, Lon protease, NQO1, ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's Version

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Publisher copy:
10.1016/j.redox.2019.101194

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Grant:
R01 ES003598
R01 ES023864
R56 ES023864
R56 ES003598
Publisher:
Elsevier Publisher's website
Journal:
Redox biology Journal website
Volume:
24
Pages:
101194
Publication date:
2019-04-14
Acceptance date:
2019-04-08
DOI:
ISSN:
2213-2317
Pubs id:
pubs:994932
URN:
uri:cace9b38-8596-4561-a49d-da82b2c71053
UUID:
uuid:cace9b38-8596-4561-a49d-da82b2c71053
Local pid:
pubs:994932

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