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Improved cellular inhibitors for glycoprotein processing alpha-glucosidases: biological characterisation of alkyl- and arylalkyl-N-substituted deoxynojirimycins

Abstract:

A series of N-alkyl- and N-arylalkyl-DNJ compounds have been evaluated for their efficacy for inhibition of endoplasmic reticulum resident α-glucosidases in cells. A recently developed free oligosaccharide (FOS) assay allowed the products of glucosidase inhibition to be quantified and compounds compared for relative inhibitory activity. A N-alkyl chain of one to six carbon atoms provided a flexible linker between deoxynojirimycin (DNJ) and a phenyl, cyclohexyl or cyclopentyl group to explore ...

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Publication status:
Published

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Journal:
TETRAHEDRON-ASYMMETRY More from this journal
Volume:
20
Issue:
6-8
Pages:
897-901
Publication date:
2009-05-07
DOI:
EISSN:
1362-511X
ISSN:
0957-4166
Language:
English
Pubs id:
pubs:101105
UUID:
uuid:cab7a7da-d8a9-4b97-b573-1722ea4349b6
Local pid:
pubs:101105
Source identifiers:
101105
Deposit date:
2012-12-19

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