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Recurrent genetic defects on chromosome 5q in myeloid neoplasms

Abstract:

BACKGROUND: Deletion of chromosome 5q (del(5q)) is the most common karyotypic abnormality in myeloid neoplasms. MATERIALS AND METHODS: To define the pathogenic molecular features associated with del(5q), next-generation sequencing was applied to 133 patients with myeloid neoplasms (MDS; N = 69, MDS/MPN; N = 5, sAML; N = 29, pAML; N = 30) with del(5q) as a sole abnormally or a part of complex karyotype and results were compared to molecular features of patients diploid for chr5. FINDINGS: A nu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.18632/oncotarget.14130

Authors


More from this funder
Name:
American Cancer Society
Grant:
Research Scholar Grant 123436-RSG-12-159-01-DMC (to TL
More from this funder
Name:
National Institutes of Health
Grant:
R01HL082983,U54RR019391
K24HL077522 toJPM,U54RR019391toMAS
More from this funder
Name:
Edward P. Evans Foundation
More from this funder
Name:
AA & MDS International Foundation
Publisher:
Impact Journals
Journal:
Oncotarget More from this journal
Volume:
8
Issue:
4
Pages:
6483-6495
Publication date:
2016-12-23
Acceptance date:
2016-12-16
DOI:
ISSN:
1949-2553
Language:
English
Keywords:
Pubs id:
pubs:667666
UUID:
uuid:cab5f11e-6c39-44c2-b93f-3d7dd1f4a188
Local pid:
pubs:667666
Source identifiers:
667666
Deposit date:
2017-01-05

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