Journal article
Hydrogen bonding phase-transfer catalysis with Potassium Fluoride: enantioselective synthesis of β-fluoroamines
- Abstract:
-
Potassium fluoride (KF) is an ideal reagent for fluorination because it is safe, easy to handle and low-cost. However, poor solubility in organic solvents coupled with limited strategies to control its reactivity has discouraged its use for asymmetric C-F bond formation. Here, we demonstrate that hydrogen bonding phase-transfer catalysis with KF provides access to valuable β-fluoroamines in high yields and enantioselectivities. This methodology employs a chiral N-ethyl bis-urea catalyst that ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- American Chemical Society Publisher's website
- Journal:
- Journal of the American Chemical Society Journal website
- Volume:
- 141
- Issue:
- 7
- Pages:
- 2878-2883
- Publication date:
- 2019-01-28
- Acceptance date:
- 2019-01-28
- DOI:
- EISSN:
-
1520-5126
- ISSN:
-
0002-7863
- Pmid:
-
30689372
Item Description
- Language:
- English
- Pubs id:
-
pubs:969006
- UUID:
-
uuid:ca83b822-2e5d-4612-9c72-16580c155d92
- Local pid:
- pubs:969006
- Source identifiers:
-
969006
- Deposit date:
- 2019-03-01
Terms of use
- Copyright holder:
- American Chemical Society
- Copyright date:
- 2019
- Notes:
- Copyright © 2019 American Chemical Society. This is an open access article published under a Creative Commons Attribution (CC-BY) License, which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
- Licence:
- CC Attribution (CC BY)
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