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Structural insights into diverse modes of ICAM-1 binding by Plasmodium falciparum-infected erythrocytes

Abstract:

A major determinant of pathogenicity in malaria caused by Plasmodium falciparum is the adhesion of parasite-infected erythrocytes to the vasculature or tissues of infected individuals. This occludes blood flow, leads to inflammation, and increases parasitemia by reducing spleen-mediated clearance of the parasite. This adhesion is mediated by PfEMP1, a multivariant family of around 60 proteins per parasite genome which interact with specific host receptors. One of the most common of these rece...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1073/pnas.1911900116

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Oxford college:
Somerville College
Role:
Author
ORCID:
0000-0002-2870-1955
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences More from this journal
Volume:
116
Issue:
40
Pages:
20124-20134
Publication date:
2019-09-16
Acceptance date:
2019-08-22
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
31527263
Language:
English
Keywords:
Pubs id:
pubs:1054970
UUID:
uuid:ca717ef2-2b76-4eb1-800c-8a7aa48bec3a
Local pid:
pubs:1054970
Source identifiers:
1054970
Deposit date:
2019-11-12

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