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Functional vitamin B12 deficiency.

Abstract:

We describe a case of functional vitamin B12 deficiency where the repeated measurement of a serum B12 level within the normal range led to delay in the diagnosis of subacute combined degeneration of the spinal cord, and possibly permanent neurological damage as a result. Failure of intracellular transport of B12 by transcobalamin-2 can lead to functional B12 deficiency but with apparently normal serum levels, and is suggested by raised levels of either serum methylmalonic acid or homocysteine...

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Publisher copy:
10.1136/jnnp.2008.161968

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Neuroscience
Journal:
Practical neurology
Volume:
9
Issue:
1
Pages:
37-41
Publication date:
2009-02-05
DOI:
EISSN:
1474-7766
ISSN:
1474-7758
URN:
uuid:ca50a386-014b-4991-849a-ea1fbf4c1305
Source identifiers:
245043
Local pid:
pubs:245043

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