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Stimulation of insulin release by repaglinide and glibenclamide involves both common and distinct processes.

Abstract:

The action of repaglinide, a novel insulin secretagogue, was compared with the sulfonylurea glibenclamide with regard to the hypoglycemic action in vivo, binding to betaTC-3 cells, insulin secretion from perifused mouse islets, and capacity to stimulate exocytosis by direct interaction with the secretory machinery in single voltage-clamped mouse beta-cells. Two binding sites were identified: a high-affinity repaglinide (KD = 3.6 nmol/l) site having lower affinity for glibenclamide (14.4 nmol/...

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Publication status:
Published

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Publisher copy:
10.2337/diabetes.47.3.345

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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
OCDEM
Role:
Author
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Journal:
Diabetes
Volume:
47
Issue:
3
Pages:
345-351
Publication date:
1998-03-01
DOI:
EISSN:
1939-327X
ISSN:
0012-1797
Source identifiers:
17318

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