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New antigens for a multicomponent blood-stage malaria vaccine.

Abstract:

An effective blood-stage vaccine against Plasmodium falciparum remains a research priority, but the number of antigens that have been translated into multicomponent vaccines for testing in clinical trials remains limited. Investigating the large number of potential targets found in the parasite proteome has been constrained by an inability to produce natively folded recombinant antigens for immunological studies. We overcame these constraints by generating a large library of biochemically act...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Tropical Medicine
Crosnier, C More by this author
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Journal:
Science translational medicine
Volume:
6
Issue:
247
Pages:
247ra102
Publication date:
2014-07-05
DOI:
EISSN:
1946-6242
ISSN:
1946-6234
URN:
uuid:ca3bd412-367b-4942-acbd-ad8760cbf658
Source identifiers:
479269
Local pid:
pubs:479269
Language:
English

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