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iPSC-derived microglia as a model to study inflammation in idiopathic Parkinson's disease

Abstract:

Parkinson’s disease (PD) is a neurodegenerative disease with unknown cause in the majority of patients, who are therefore considered “idiopathic” (IPD). PD predominantly affects dopaminergic neurons in the substantia nigra pars compacta (SNpc), yet the pathology is not limited to this cell type. Advancing age is considered the main risk factor for the development of IPD and greatly influences the function of microglia, the immune cells of the brain. With increasing age, microglia become dysfu...

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Publication status:
Published
Peer review status:
Peer reviewed

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Files:
Publisher copy:
10.3389/fcell.2021.740758

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Publisher:
Frontiers Media
Journal:
Frontiers in Cell and Developmental Biology More from this journal
Volume:
9
Article number:
740758
Publication date:
2021-11-05
Acceptance date:
2021-10-08
DOI:
EISSN:
2296-634X
Pmid:
34805149
Language:
English
Keywords:
Pubs id:
1215003
Local pid:
pubs:1215003
Deposit date:
2021-12-17

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