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Transcription reinitiation by recycling RNA polymerase that diffuses on DNA after releasing terminated RNA

Abstract:

Despite extensive studies on transcription mechanisms, it is unknown how termination complexes are disassembled, especially in what order the essential components dissociate. Our single-molecule fluorescence study unveils that RNA transcript release precedes RNA polymerase (RNAP) dissociation from the DNA template much more often than their concurrent dissociations in intrinsic termination of bacterial transcription. As termination is defined by the release of product RNA from the t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41467-019-14200-3

Authors


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Institution:
University of Oxford
Division:
MPLS
Department:
Physics
Sub department:
Condensed Matter Physics
Role:
Author
ORCID:
0000-0001-8993-3955
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Role:
Author
ORCID:
0000-0002-5726-9022
Publisher:
Springer Nature
Journal:
Nature Communications More from this journal
Volume:
11
Article number:
450
Publication date:
2020-01-23
Acceptance date:
2019-12-10
DOI:
EISSN:
2041-1723
Pmid:
31974350
Language:
English
Keywords:
Pubs id:
1085661
Local pid:
pubs:1085661
Deposit date:
2020-10-02

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