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Predicting cognitive resilience from midlife lifestyle and multi-modal MRI: A 30-year prospective cohort study

Abstract:
Background There is significant heterogeneity in the clinical expression of structural brain abnormalities, including Alzheimer’s disease biomarkers. Some individuals preserve their memory despite the presence of risk factors or pathological brain changes, indicating resilience. We aimed to test whether resilient individuals could be distinguished from those who develop cognitive impairment, using sociodemographic variables and neuroimaging. Methods We incl... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0211273

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Psychiatry
Role:
Author
More from this funder
Name:
European Commission
Grant:
732592
More from this funder
Name:
Medical Research Council
Grant:
G1001354
Publisher:
Public Library of Science
Journal:
PLoS ONE More from this journal
Volume:
14
Issue:
2
Article number:
e0211273
Publication date:
2019-02-19
Acceptance date:
2019-01-11
DOI:
EISSN:
1932-6203
Pubs id:
pubs:959305
UUID:
uuid:ca23924d-76e4-457d-9cc2-bb62eee6e716
Local pid:
pubs:959305
Source identifiers:
959305
Deposit date:
2019-01-12

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