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Epigenetic blockade of neoplastic transformation by bromodomain and extra-terminal (BET) domain protein inhibitor JQ-1

Abstract:

The neoplastic transformation of cells and inflammation are processes that contribute to tumor initiation. Recently, emerging evidence has suggested that epigenetic alterations are also implicated in the early stages of carcinogenesis. Therefore, potent small molecules targeting epigenetic regulators have been developed as novel cancer therapeutic and preventive strategies. Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that play key roles at the interface between ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bcp.2016.08.009

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Role:
Author
ORCID:
0000-0002-2062-3278
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Publisher:
Elsevier Publisher's website
Journal:
Biochemical Pharmacology Journal website
Volume:
117
Pages:
35-45
Publication date:
2016-10-01
Acceptance date:
2016-08-08
DOI:
EISSN:
1873-2968
ISSN:
0006-2952
Pmid:
27520485
Source identifiers:
640783
Language:
English
Keywords:
Pubs id:
pubs:640783
UUID:
uuid:ca20703d-c314-4c5c-bf8b-d9fceddf614b
Local pid:
pubs:640783
Deposit date:
2018-06-26

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