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Effect of 5 Genetic Variants Associated with Lung Function on the Risk of COPD, and their Joint Effects on Lung Function.

Abstract:

RATIONALE: Genomic loci are associated with forced expiratory volume in one second (FEV1) or the ratio of FEV1 to forced vital capacity (FVC) in population samples, but their association with COPD has not yet been proven, nor have their combined effects on lung function and COPD been studied. OBJECTIVES: To test association with COPD of variants at five loci (TNS1, GSTCD, HTR4, AGER and THSD4) and evaluate joint effects on lung function and COPD of these SNPs, and variants at the previously r...

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Publisher copy:
10.1164/rccm.201102-0192OC

Authors


Soler Artigas, M More by this author
Obeidat, M More by this author
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Journal:
Am J Respir Crit Care Med
Volume:
184
Issue:
7
Pages:
786-795
Publication date:
2011-06-16
DOI:
EISSN:
1535-4970
ISSN:
1073-449X
URN:
uuid:ca1e9223-c120-4ff9-8417-64b219520fed
Source identifiers:
155690
Local pid:
pubs:155690

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