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Journal article

The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

Abstract:

In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca(2+) mobilisation. In addition, we describe how TPCs may also trigger further Ca(2+) release by coupling to the en...

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Publication status:
Published

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Publisher copy:
10.1007/s00424-009-0682-y

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Pharmacology
Role:
Author
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Journal:
Pflugers Archiv : European journal of physiology
Volume:
458
Issue:
5
Pages:
869-876
Publication date:
2009-09-01
DOI:
EISSN:
1432-2013
ISSN:
0031-6768
Source identifiers:
56426
Language:
English
Keywords:
Pubs id:
pubs:56426
UUID:
uuid:ca1cb4c8-c393-4448-aac5-d5bf3f659d2e
Local pid:
pubs:56426
Deposit date:
2012-12-19

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