The acid test: the discovery of two-pore channels (TPCs) as NAADP-gated endolysosomal Ca(2+) release channels.

Journal article

In this review, we describe the background and implications of our recent discovery that two-pore channels (TPCs) comprise a novel class of calcium release channels gated by the intracellular messenger nicotinic acid adenine dinucleotide phosphate (NAADP). Their localisation to the endolysosomal system highlights a new function for these organelles as targets for NAADP-mediated Ca(2+) mobilisation. In addition, we describe how TPCs may also trigger further Ca(2+) release by coupling to the endoplasmic reticular stores through activation of IP(3) receptors and ryanodine receptors.

Authors: Galione, A; Evans, A; Ma, J; Parrington, J; Arredouani, A

• Publication status: Published
• Journal: Pflugers Archiv : European journal of physiology
• Volume: 458
• Issue: 5
• Pages: 869-876
• Publication date: 2009-09-01
• DOI: 10.1007/s00424-009-0682-y
• EISSN: 1432-2013
• ISSN: 0031-6768
• Language: English
• Keywords: Calcium Channels; Calcium Signaling; Humans; Lysosomes; NADP; Models, Molecular; Animals; Ion Channel Gating; Phylogeny; Endosomes