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Consanguinity and susceptibility to infectious diseases in humans.

Abstract:

Studies of animal populations suggest that low genetic heterozygosity is an important risk factor for infection by a diverse range of pathogens, but relatively little research has looked to see whether similar patterns exist in humans. We have used microsatellite genome screen data for tuberculosis (TB), hepatitis and leprosy to test the hypothesis that inbreeding depression increases risk of infection. Our results indicate that inbred individuals are more common among our infected cases for ...

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Publication status:
Published

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Publisher copy:
10.1098/rsbl.2009.0133

Authors


Frodsham, AJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Journal:
Biology letters
Volume:
5
Issue:
4
Pages:
574-576
Publication date:
2009-08-05
DOI:
EISSN:
1744-957X
ISSN:
1744-9561
URN:
uuid:ca1c7b30-e8c8-474c-ac53-ae98996f5015
Source identifiers:
34662
Local pid:
pubs:34662

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