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NRF2 and hypoxia inducible factors: key players in the redox control of systemic iron homeostasis

Abstract:

Significance: Oxygen metabolism and iron homeostasis are closely linked. Iron facilitates the oxygen-carrying capacity of blood, and its deficiency causes anaemia. Conversely, excess free iron is detrimental for stimulating the formation of reactive oxygen species, causing tissue damage. The amount and distribution of iron thus need to be tightly regulated by the liver-expressed hormone hepcidin. This review analyses the roles of key oxygen-sensing pathways in cellular and systemic regulation...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1089/ars.2020.8148

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
ORCID:
0000-0002-9186-8950
Publisher:
Mary Ann Liebert, Inc. Publishers
Journal:
Antioxidants and Redox Signaling More from this journal
Volume:
35
Issue:
6
Pages:
433-452
Publication date:
2020-08-13
Acceptance date:
2020-08-11
DOI:
EISSN:
1557-7716
ISSN:
1523-0864
Pmid:
32791852
Language:
English
Keywords:
Pubs id:
1126427
Local pid:
pubs:1126427
Deposit date:
2020-08-16

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