Association of age with 10-year outcomes after coronary surgery in the Arterial Revascularization Trial

Journal article

Background

The association of age with the outcomes of bilateral internal thoracic arteries (BITAs) versus single internal thoracic arteries (SITAs) for coronary bypass grafting (CABG) remains to be determined.

Objectives

The purpose of this study was to evaluate the association between age and BITA versus SITA outcomes in the Arterial Revascularization Trial.

Methods

The primary endpoints were all-cause mortality and a composite of major adverse events, including all-cause mortality, myocardial infarction, or stroke. Secondary endpoints were bleeding complications and sternal wound complications up to 6 months after surgery. Multivariable fractional polynomials analysis and log-rank tests were used.

Results

Age did not affect any of the explored outcomes in the overall BITA versus SITA comparison in the intention-to-treat analysis and in the analysis based on the number of arterial grafts received. However, when the intention-to-treat analysis was restricted to the populations of patients between age 50 and 70 years, younger patients in the BITA arm had a significantly lower incidence of major adverse events (p = 0.03).

Conclusions

Our results suggest that BITA may improve long-term outcome in younger patients, although more randomized data are needed to confirm this hypothesis.

Authors: Gaudino, M; Di Franco, A; Flather, M; Gerry, S; Bagiella, E

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier
• Journal: Journal of the American College of Cardiology
• Volume: 77
• Issue: 1
• Pages: 18-26
• Publication date: 2021-01-04
• Acceptance date: 2020-10-25
• DOI: 10.1016/j.jacc.2020.10.047
• EISSN: 1558-3597
• ISSN: 0735-1097
• Language: English
• Keywords: CABG; FFR; bilateral internal thoracic arteries; single internal thoracic artery