Journal article
Studying a propionic acidaemia mouse model reveals epigenetic mechanisms in the heart
- Abstract:
- We show how a build-up of propionyl-CoA in a mouse model of propionic acidaemia produces histone modifications in the heart. The transcriptional responses included genes implicated in contractile dysfunction. Notably, female mice are more severely affected, owing to a protective effect of β-alanine in males, a therapeutically important finding.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Access Document
- Files:
-
-
(Preview, Accepted manuscript, pdf, 15.5MB, Terms of use)
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- Publisher copy:
- 10.1038/s44161-023-00371-2
Authors
- Publisher:
- Springer Nature
- Journal:
- Nature Cardiovascular Research More from this journal
- Volume:
- 2
- Issue:
- 12
- Pages:
- 1125-1126
- Publication date:
- 2023-11-29
- DOI:
- EISSN:
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2731-0590
- Language:
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English
- Keywords:
- Pubs id:
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1602474
- Local pid:
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pubs:1602474
- Deposit date:
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2024-02-25
- ARK identifier:
Terms of use
- Copyright holder:
- Swietach and Park
- Copyright date:
- 2023
- Rights statement:
- © The Author(s) 2023
- Notes:
- This is the accepted manuscript version of the article. The final version is available online from Springer Nature at: https://dx.doi.org/10.1038/s44161-023-00371-2
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