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Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis

Abstract:

Background: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival.

Methods: In this multicohort study, we used five sepa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S1470-2045(18)30294-8

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
ORCID:
0000-0003-4654-7311
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
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Funding agency for:
Kanellakis, N
Grant:
STRTF 2015-9508
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Funding agency for:
Hallifax, R
Grant:
MR/L017091/1
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Funding agency for:
Pavord, I
Grant:
RESPIRE2 – 2015–7160
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Funding agency for:
Stathopoulos, G
Grant:
679345
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Publisher:
Elsevier Publisher's website
Journal:
Lancet Oncology Journal website
Volume:
19
Issue:
7
Pages:
930-939
Publication date:
2018-06-13
Acceptance date:
2018-04-11
DOI:
EISSN:
1474-5488
ISSN:
1470-2045
Source identifiers:
836582
Pubs id:
pubs:836582
UUID:
uuid:c9eff614-3804-4c71-9f82-d8654d82c874
Local pid:
pubs:836582
Deposit date:
2018-04-16

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