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Development and validation of response markers to predict survival and pleurodesis success in patients with malignant pleural effusion (PROMISE): a multicohort analysis

Abstract:

Background: The prevalence of malignant pleural effusion is increasing worldwide, but prognostic biomarkers to plan treatment and to understand the underlying mechanisms of disease progression remain unidentified. The PROMISE study was designed with the objectives to discover, validate, and prospectively assess biomarkers of survival and pleurodesis response in malignant pleural effusion and build a score that predicts survival.

Methods: In this multicohort study, we used five sepa...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/S1470-2045(18)30294-8

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; NDM Experimental Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Sub department:
Centre for Statistics in Medicine
Role:
Author
ORCID:
0000-0003-4654-7311
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Target Discovery Institute
Role:
Author
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Name:
European Research Council
Funding agency for:
Stathopoulos, G
Grant:
679345
More from this funder
Name:
Medical Research Council
Funding agency for:
Hallifax, R
Grant:
MR/L017091/1
More from this funder
Name:
European Respiratory Society
Funding agency for:
Kanellakis, N
Pavord, I
Grant:
STRTF 2015-9508
RESPIRE2 – 2015–7160
*Grant Number Example*
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Name:
Oxfordshire Health Services Research Committee Research Grants
Grant:
*Grant Number Example*
More from this funder
Name:
Slater and Gordon Research Fund
Grant:
*Grant Number Example*
Publisher:
Elsevier
Journal:
Lancet Oncology More from this journal
Volume:
19
Issue:
7
Pages:
930-939
Publication date:
2018-06-13
Acceptance date:
2018-04-11
DOI:
EISSN:
1474-5488
ISSN:
1470-2045
Pubs id:
pubs:836582
UUID:
uuid:c9eff614-3804-4c71-9f82-d8654d82c874
Local pid:
pubs:836582
Source identifiers:
836582
Deposit date:
2018-04-16

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