Journal article

Exploiting the defensive sugars of HIV-1 for drug and vaccine design

Abstract:: The sustained effort towards developing an antibody vaccine against HIV/AIDS has provided much of our understanding of viral immunology. It is generally accepted that one of the main barriers to antibody neutralization of HIV is the array of protective structural carbohydrates that covers the antigens on the virus's surface. Intriguingly, however, recent findings suggest that these carbohydrates, which have evolved to protect HIV and promote its transmission, are also attractive therapeutic targets.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Scanlan, C., Offer, J., Zitzmann, N., & Dwek, R. (2007). Exploiting the defensive sugars of HIV-1 for drug and vaccine design. Nature, 446(7139), 1038–1045.

MLA Style

Scanlan, C., et al. “Exploiting the Defensive Sugars of HIV-1 for Drug and Vaccine Design.” Nature, vol. 446, no. 7139, Nature Research, 2007, pp. 1038–45.

Chicago Style

Scanlan, C, J Offer, N Zitzmann, and R Dwek. 2007. “Exploiting the Defensive Sugars of HIV-1 for Drug and Vaccine Design.” Nature 446 (7139): 1038–45.
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Publisher copy:: 10.1038/nature05818

Authors

+ Scanlan, C More by this author

Role:: Author

+ Offer, J More by this author

Role:: Author

+ Zitzmann, N More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Biochemistry
Role:: Author

+ Dwek, R More by this author

Institution:: University of Oxford
Division:: MSD
Department:: Biochemistry
Role:: Author

Publisher:: Nature Research
Journal:: Nature More from this journal
Volume:: 446
Issue:: 7139
Pages:: 1038-1045
Publication date:: 2007-04-25
DOI:: 10.1038/nature05818
EISSN:: 1476-4687
ISSN:: 0028-0836

Language:: English
Keywords:: HIV-1

AIDS vaccines

anti-HIV agents

HIV antigens

drug design

carbohydrates
Pubs id:: pubs:99986
UUID:: uuid:c9ecb654-9f7e-4df8-a61c-f60f9af76d17
Local pid:: pubs:99986
Source identifiers:: 99986
Deposit date:: 2012-12-19

Terms of use

Copyright holder:: Nature Publishing Group
Copyright date:: 2007
Notes:: © 2007 Nature Publishing Group.

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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