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Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length

Abstract:

The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association ...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1093/hmg/ddy317

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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM; Big Data Institute
Role:
Author
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Funding agency for:
Lindgren, CM
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Funding agency for:
Lindgren, CM
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Funding agency for:
Lindgren, CM
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
27
Issue:
24
Pages:
4323–4332
Publication date:
2018-09-20
Acceptance date:
2018-09-03
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pubs id:
pubs:891020
URN:
uri:c9e42a84-fb6d-462f-9060-dc18c6044674
UUID:
uuid:c9e42a84-fb6d-462f-9060-dc18c6044674
Local pid:
pubs:891020

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