Journal article
Large-scale meta-analysis highlights the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length
- Abstract:
- The normal menstrual cycle requires a delicate interplay between the hypothalamus, pituitary and ovary. Therefore, its length is an important indicator of female reproductive health. Menstrual cycle length has been shown to be partially controlled by genetic factors, especially in the follicle-stimulating hormone beta-subunit (FSHB) locus. A genome-wide association study meta-analysis of menstrual cycle length in 44 871 women of European ancestry confirmed the previously observed association with the FSHB locus and identified four additional novel signals in, or near, the GNRH1, PGR, NR5A2 and INS-IGF2 genes. These findings not only confirm the role of the hypothalamic–pituitary–gonadal axis in the genetic regulation of menstrual cycle length but also highlight potential novel local regulatory mechanisms, such as those mediated by IGF2.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 4.5MB, Terms of use)
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- Publisher copy:
- 10.1093/hmg/ddy317
Authors
+ National Institutes of Health
More from this funder
- Funding agency for:
- Lindgren, C
- Grant:
- 5P50HD028138-27
- Common Complex Trait Genetics of Reproductive Phenotypes; grant 5P50HD028138-27
+ European Commission
More from this funder
- Funding agency for:
- Lindgren, C
- Grant:
- 5P50HD028138-27
- WIDENLIFE, grant number 692065
+ Li Ka Shing
Foundation
More from this funder
- Funding agency for:
- Lindgren, C
- Grant:
- 5P50HD028138-27
+ NIHR Oxford Biomedical Research Centre
More from this funder
- Funding agency for:
- Ferreira, T
- Lindgren, C
- Grant:
- 5P50HD028138-27
- Publisher:
- Oxford University Press
- Journal:
- Human Molecular Genetics More from this journal
- Volume:
- 27
- Issue:
- 24
- Pages:
- 4323–4332
- Publication date:
- 2018-09-20
- Acceptance date:
- 2018-09-03
- DOI:
- EISSN:
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1460-2083
- ISSN:
-
0964-6906
- Pubs id:
-
pubs:891020
- UUID:
-
uuid:c9e42a84-fb6d-462f-9060-dc18c6044674
- Local pid:
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pubs:891020
- Deposit date:
-
2018-09-13
Terms of use
- Copyright holder:
- Laisk et al
- Copyright date:
- 2018
- Notes:
- Copyright © 2018 The Authors. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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