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Protein arginine methylation: a prominent modification and its demethylation

Abstract:

Arginine methylation of histones is one mechanism of epigenetic regulation in eukaryotic cells. Methylarginines can also be found in non-histone proteins involved in various different processes in a cell. An enzyme family of nine protein arginine methyltransferases catalyses the addition of methyl groups on arginines of histone and non-histone proteins, resulting in either mono- or dimethylated-arginine residues. The reversibility of histone modifications is an essential feature of epigenetic...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1007/s00018-017-2515-z

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
Publisher:
Springer International Publishing Publisher's website
Journal:
Cellular and Molecular Life Sciences Journal website
Volume:
74
Issue:
18
Pages:
3305–3315
Publication date:
2017-03-31
Acceptance date:
2017-03-28
DOI:
EISSN:
1420-9071
ISSN:
1420-682X
Language:
English
Keywords:
Pubs id:
pubs:688802
UUID:
uuid:c9d7270a-4c59-4e53-afd1-87debb392b68
Local pid:
pubs:688802
Source identifiers:
688802
Deposit date:
2017-04-12

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