SPATA2 links CYLD to LUBAC, activates CYLD and controls LUBAC signaling
The Linear UBiquitin chain Assembly Complex (LUBAC) regulates immune signaling and its function is regulated by the deubiquitinases OTULIN and CYLD that associate with the catalytic subunit HOIP. However, the mechanism through which CYLD interacts with HOIP is unclear. We here show that CYLD interacts with HOIP via spermatogenesis-associated protein 2 (SPATA2). SPATA2 interacts with CYLD through its non-canonical PUB domain that binds the catalytic CYLD USP domain in a CYLD B-box-dependent ma...Expand abstract
- Publication status:
- Peer review status:
- Peer reviewed
- Pubs id:
- Local pid:
- Deposit date:
- Copyright holder:
- Elliott et al
- Copyright date:
Copyright © 2016 The Authors. Published by Elsevier Inc.
This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record