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Journal article

SPATA2 links CYLD to LUBAC, activates CYLD and controls LUBAC signaling

Abstract:

The Linear UBiquitin chain Assembly Complex (LUBAC) regulates immune signaling and its function is regulated by the deubiquitinases OTULIN and CYLD that associate with the catalytic subunit HOIP. However, the mechanism through which CYLD interacts with HOIP is unclear. We here show that CYLD interacts with HOIP via spermatogenesis-associated protein 2 (SPATA2). SPATA2 interacts with CYLD through its non-canonical PUB domain that binds the catalytic CYLD USP domain in a CYLD B-box-dependent ma...

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Publication status:
Published
Peer review status:
Peer reviewed

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  • (Version of record, pdf, 11.7MB)
Publisher copy:
10.1016/j.molcel.2016.08.001

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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More from this funder
Funding agency for:
Kessler, B
Grant:
097813/Z/11/Z
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Funding agency for:
Kessler, B
Grant:
097813/Z/11/Z
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Funding agency for:
Gyrd-Hansen, M
Grant:
Sapere Aude Starting Grant
More from this funder
Funding agency for:
Gyrd-Hansen, M
Grant:
Sapere Aude Starting Grant
More from this funder
Funding agency for:
Gyrd-Hansen, M
Grant:
Sapere Aude Starting Grant
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Publisher:
Cell Press Publisher's website
Journal:
Molecular Cell Journal website
Volume:
63
Issue:
6
Pages:
990–1005
Publication date:
2016-08-30
Acceptance date:
2016-07-29
DOI:
ISSN:
1097-4164
Source identifiers:
636510
Pubs id:
pubs:636510
UUID:
uuid:c9ca6f91-b752-4ff1-a7b2-c00953e3c7cb
Local pid:
pubs:636510
Deposit date:
2016-07-29

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