Journal article
Association between metabolic syndrome and risk of incident dementia in UK Biobank
- Abstract:
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INTRODUCTION: The association between metabolic syndrome (MetS) and incident dementia remains inconclusive.
METHODS: In 176,249 dementia-free UK Biobank participants aged ≥60 years at baseline, Cox proportional-hazards models were used to investigate the association between MetS and incident dementia. MetS was defined as the presence of ≥3 of the following: elevated waist circumference, triglycerides, blood pressure, blood glucose, and reduced high-density lipoprotein cholesterol.
RESULTS: Over 15 years of follow-up (median = 12.3), 5255 participants developed dementia. MetS was associated with an increased risk of incident dementia (hazard ratio [HR]: 1.12, 95% confidence interval [CI]: 1.06, 1.18). The association remained consistent when restricting to longer follow-up intervals: >5 to 10 years (HR: 1.17, 95% CI: 1.07, 1.27) and >10 years (HR: 1.22, 95% CI: 1.12, 1.32). Stronger associations were observed in those with ≥4 MetS components and in apolipoprotein-E (APOE)-ε4 non-carriers.
DISCUSSION: In this large population-based prospective cohort, MetS was associated with an increased risk of dementia.
Highlights • MetS was associated with a 12% increased risk of incident all-cause dementia. • Associations remained similar after restricting the analysis to those with longer follow-up. • The presence of four or five MetS components was significantly associated with dementia. • Stronger associations were observed in those with a low genetic risk for dementia.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 524.5KB, Terms of use)
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- Publisher copy:
- 10.1002/alz.13439
Authors
- Publisher:
- Wiley
- Journal:
- Alzheimer's & Dementia More from this journal
- Volume:
- 20
- Issue:
- 1
- Pages:
- 447-458
- Publication date:
- 2023-09-07
- Acceptance date:
- 2023-07-29
- DOI:
- EISSN:
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1552-5279
- ISSN:
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1552-5260
- Language:
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English
- Keywords:
- Pubs id:
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1522775
- Local pid:
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pubs:1522775
- Deposit date:
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2023-09-08
Terms of use
- Copyright holder:
- Qureshi et al
- Copyright date:
- 2023
- Rights statement:
- © 2023 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
- Notes:
- For the purpose of open access, the authors have applied a Creative Commons Attribution (CCBY) license to any author accepted manuscript version arising.
- Licence:
- CC Attribution (CC BY)
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